Androgen structure

Therapeutic Function Androgen anabolic Chemical Name 17/J-Hydroxy-l 7-methylandrosta-1,4-dien-3-one Common Name Methandienone Structural Formula ... 

Sex Steroid Receptors Androgen Receptor, Estrogen Receptors, Progesterone Receptor. Figure 1 Schematic structures of AR, ERa, ER(3, and PR. 

The single crystal X-ray structure of the enantiopure tetrahydro oxepin-2-one 61, a mimic of steroidal androgens, has been reported <06ZN(B)111>. A new procedure has been described for the synthesis of substituted furano-fused oxepines based on expoxidation of strained fused cyclobutenes followed by thermal rearrangement <06OL5183>. 

Men with disease fixed or invading adjacent structures other than the seminal vesicles (T4) are at very high risk for recurrence. Androgen ablation should be initiated at diagnosis instead of waiting for the onset of symptoms. 

Flutamide, an androgen receptor antagonist possessing a different chemical structure, lacks progestin activity. 

---