Andrachne aspera

Floreancig and Hood recently incorporated gold-catalyzed heterocycle formation in the total synthesis of (+)-Andrachcinidine, a natural component extracted from the plant Andrachne aspera, which has medicinal properties. Gold catalysis was required in the last step of the synthesis, as shown in Scheme 8.22 [119]. 

A crude alkaloid extract of the shrub Andrachne aspera had been found to show antibacterial and other biological activity [503]. A new alkaloid, andrachamine (227) was isolated from this... 

A second new alkaloid, andrachcine (228) was isolated from Andrachne aspera. Its structure was determined using HRMS, IR, UV and lH NMR. Once again, application of the Horeau method led to assignment of the absolute configuration at the hydroxylated carbons as S,S [506],... 

---