And temporal lobe epilepsy

Elood JE, Earr SA, Uezo K, et al The pharmacology of post-trial memory processing in septum. Eur. J Pharmacol 350 31-38, 1998 Elor-Henry P Psychosis and temporal lobe epilepsy a controlled investigation. Epilepsia 10 363-395, 1969... 

Phenobarbitone is useful in grandmal, focal and temporal lobe epilepsy and sometimes petitmal also. It is also useful in the treatment of febrile convulsions. 

The PGO waves of REM sleep are epileptiform. Both consist of spike and wave EEG complexes that are morphologically indistinguishable. In both PGO waves and temporal lobe epilepsy, these spike and wave complexes are generated by similar mechanisms owing to a physiological decline in inhibitory modulation (REM sleep) or to structural damage (TEE), neurons are disinhibited and fire in intense bursts, of which the EEG spike and wave complex is the extracellular record. 

It is frequently employed as an anticonvulsant in the management and treatment of grand mal, petit mal, mixed and temporal lobe epilepsy. 

The seizure control of 54 children with grand mal and temporal lobe epilepsy was improved when acetazolamide 10 mg/kg daily was added to carbamazepine. Serum carbamazepine levels rose by 1 to 6 mg/L in 60% of the 33 patients sampled. Adverse effects developed in 10 children, and in 8 children this was within 1 to 10 days of starting the acetazolamide. The adverse effects responded to a reduction in the carbamazepine dosage. ... 

Complex partial seizures manifest themselves as bizarre behaviours which are also known as psychomotor or temporal lobe epilepsy, since a lesion (focus) is often found in that brain area. Repetitive and apparently purposeful movements vary from simple hand clenching or rubbing to more bizarre hand movements and walking. These can last a few minutes, often disrupt other ongoing activity or speech and the patient has no subsequent memory of them. Complex seizures may develop from simple ones. 

Isokawa, M, Levesque, MF, Babb, TL and Engel Jr, J (1993) Single mossy fibre axonal systems of human dentate granule cells studied in hippo-campal slices from patients with temporal lobe epilepsy. J. Neurosci. 13 1511-1522. 

Isokawa, M, Levesque, M, Fried, I and Engel, J Jr (1997) Glutamate currents in morphologically identified human dentate granule cells in temporal lobe epilepsy. J. Neurophysiol. 77 3355-3369. 

Buhl, E. H., Otis, T. S. and Mody, I. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science 271 369-373,1996. 

Bouilleret V, Ridoux V, Depaulis A, Marescaux C, Nehlig A, he Gal La Salle G (1999) Recurrent seizures andhippocampal sclerosis followingintrahippocampalkainite injection in adult mice EEG, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy. Neuroscience 89 7171-7729... 

Bouilleret V, Loup F, Kiener T, Marescaux C, Fritschy JM (2000) Early loss of internemons and delayed subunit-specific changes in GABAA-receptor expression in a mouse model of mesial temporal lobe epilepsy. Hippocampus 10 305-324... 

Bear, D.M. and Fedio, P. (1977) Quantitative analysis of interictal behavior in temporal lobe epilepsy. Arch Neurol 34 454—467. 

Woermann, EG., van Elst, L.T., Koepp, M.J., Free, S.L., Thompson, P.J., Trimble, M.R., and Duncan, J.S. (2000) Reduction of frontal neocortical grey matter associated with affective aggression in patients with temporal lobe epilepsy an objective voxel by voxel analysis of automatically segmented MRI. / Neurol Neurosurg Psychiatry 68 162-169. 

Various religious prophets such as Saint Paul, Ezekiel, and Mohammed may have suffered from epileptic seizures. Recently, several nuns with temporal lobe epilepsy (TLE) have provided evidence that TLE is the root of many mystical religious experiences. For example, one former nun apprehended God in TLE seizures and described the experience ... 

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