Anaphylaxis anaphylactic reactions drug-induced

Anaphylactic reactions to celery have been reported, including two cases of food-dependent, exercise-induced anaphylaxis after ingestion of celery (Barg et al. 2008 Vilke 2002). One case of anaphylactic reaction to the drug oseltamivir (Tamiflu) occurred in a patient with celery-carrot-mugwort-spice syndrome (Hirschfeld et al. 2008). 

Once sensitivity has been established, that is, once hapten-specific IgE-producing B cells have been formed, exposure to even small amounts of hapten can induce a cascade of events that lead to immediate reactions, such as anaphylaxis (210). Briefly, preformed IgE antibodies to drug determinants recognize the hapten-carrier complex and fix to the surface of mast cells or basophils, triggering the release of a series of mediators, such as histamine, neutral proteases, biologically active arachidonic acid products, and cytokines. This ultimately leads to a clinical spectrum that ranges from a mUd local reaction to anaphylactic shock. 

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