Anaphylactic reactions intravenous immunoglobulin

Some reports suggest that anaphylaxis due to intravenous immunoglobulin infusion occurs most often in patients with primary hypogammaglobulinemia (115,116). However, anaphylactic reactions have been seen in two atopic patients with idiopathic thrombocytopenic purpura, and the authors warned that children with atopic disease should not receive intravenous immunoglobulin (117). 

Immunologic IgA-deficient patients with anti-IgA antibodies may form macromolec-ular complexes after administration of intravenous immunoglobulin, possibly leading to anaphylactic reactions. This can be prevented by using IgA-depleted intravenous immunoglobulin, even if it still contains a small amount of IgA [39 ]. Some adverse reactions can be associated with activation of the complement cascade, in which formation of IgG aggregates could play a role [fiC],... 

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