Analysis of Tropane Alkaloids in Biological Matrices

Philippe Christen, Stefan Bieri, Jean-Luc Veuthey 

Modem Alkaloids Structure, Isolation, Synthesis and Biology. Edited by E. Fattorusso and O. Taglialatela-Scafati Copyright 2008 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-31521-5 

Semisynthetic derivatives have also been commercialized. These compounds are quaternary derivatives that have no side effects on the central nervous system. They are used against spasm of the bladder or of the intestine and to treat bronchospasm associated vdth chronic obstructive pulmonary disease. 

Owing to their structural similarity with monosaccharides, calystegmes exhibit potent inhibitory activities against glycosidases. Thus, they are of considerable interest as potential antiviral, anticancer, and antidiabetic agents. The pharmacological properties of these compounds have been comprehensively reviewed [9,6]. 

In this review, plant material and numerous biological fluids, mainly blood plasma and serum, urine, and saliva, as well as some alternative matrices such as bile, amniotic fluid, cord blood, meconium, and maternal hair among others will be 

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Ciisten P, Bieri S, Venthey J (2008) Analysis of tropane alkaloids in biological matrices. In Fattorusso E, Tagliatela-Scafati O (eds) Modem alkaloids stmcture, isolation, synthesis and biology. Wiley, Weinhein, p 341... 

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