Analysis of Chromatographic Elution Curves

The coefficients k, and K represent the adsorption rate constant and adsorption equilibrium constant, respectively. In the above equations, Pp and Cp are the particle density and porosity of the particle, and C, c. and 9i denote concentrations of the component in the fluid phase, in the pores of the particle, and adsorbed on the particle, respectively. 

Pore diffusion kinetics is assumed to be dominant in Eqs. (6-2) and (6-3) but it is easily extended to the case of dominant surface diffusion kinetics by taking ppK D, instead of D, in these equations, since a linear isotherm relation is assumed here. 

The chromatographic experiment, based on introducing a pulse of adsorbable tracer of concentration Co and duration time r into the entrance of the bed, is illustrated in Fig. 6.1. For quantitative analysis of the effluent peak Ce(r), there are several alternative techniques to determine model parameters by comparing the mathematical solution of the fundamental equations and the experimental results. These are 1) 

Since curve fitting methods both in time domain and in imaginary 

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