Analogical approaches application strategies

Figure 10.25 Inverted approach for aldose synthesis using FruA catalysis, and application ofthe strategy for deoxysugar synthesis based on a phosphorothioate analog synthesis of 1-deoxysugars by FSA catalyzed addition of hydroxyacetone.

My question to Prof. B. Kohler (as representative of the group of K. R. Wilson) is whether he would agree with S. A. Rice s classification that puts the technique of K. R. Wilson et al. [8] into strategy (ii) What are the fundamental analogies and what are the differences between their approach [8] and the Tannor-Rice-Kosloff-Rabitz approach (see Refs. 2 and 3 and current chapter) Finally, I should like to point to another strategy (iii) of laser control by vibrationally mediated chemistry that is achieved by IR + UV continuous-wave (CW) multiphoton transitions (see the pioneering papers by Letokhov [9] and sequel theoretical developments [10] and experimental applications [11]). 

The synthesis of ipalbidine (125), the aglycon of ipalbine, was based on a related approach. The vi-nylogous carbamate (123) was prepared from the V-alkylated thiobutyrolactam (122) via an analogous sulfide-contraction process as described above (Scheme 26). The bicyclic intermediate (124) was generated by selective hydrolysis of the saturated ester followed by immediate treatment with methyl chloro-formate in the presence of catalytic tetrabutylammonium iodide. The bicyclic compound (124) was further elaborate to racemic ipalbidine (125). Parallel applications of this strategy were employed to prepare a series of Elaeocarpus alkaloids (126), (127) and (128) (Scheme 27) as well a benzomorphan analog (129 Scheme 28). °... 

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