AMPA receptors agonists

Ebert, B Lenz, S. M Brehm, L Bregnedal, P Hansen, J. J., Frederiksen, K., et al. (1994) Resolution, absolute stereochemistry, and pharmacology of the S -(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,5)-2-amino-3-(3-hydroxy-5-phcnylisoxazol-... 

Some derivatives of adamantane with antagonist or agonist effects have also been synthesized. For instance, monocationic and dicationic adamantane derivatives block the a-amino-3-hydroxy-5-methylisoxazole -propionic acid (AMPA) receptors, A-methyl-o-aspartate (NMDA) receptors [134—136] and 5-hydroxytryptamine (5-HT3) receptors [137]. 

Hogner, A., Kastrup, J. S Jin, R., Liljefors, T Mayer, M. L., Egebjerg, J., et al. (2002) Structural basis for AMPA receptor activation and ligand selectivity crystal structures of five agonist complexes with the GluR2 binding core../. Mol. Biol. 322,93-109. 

Coquelle, T., Christensen, J. K Banke T. G., Madsen, U Schousboe, A., and Pickering, D. S. (2000) Agonist discrimination between AMPA receptor subtypes. NeuroReport 11, 2643-2648. 

Campiani, G., Morelli, E., Nacci, V., Fattorusso, C., Ramunno, A., Novellino, E., et al. (2001) Characterization of the l//-Cyclopentapyrimidine-2,4( I //,3//)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. J. Med. Chem. 44,4501 1504. 

Stcnsbpl, T. B Madsen, U., and Krogsgaard-Larsen, P. (2002) The AMPA receptor binding site focus on agonists and competitive antagonists. Curr. Pharm. Design 8, 857-872. 

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