AMP-thymidine kinase

AMP deoxythymidine 5 -phosphotransferase AMP deoxythymidine kinase adenylate-nucleoside phosphotransferase adenylic acid deoxythymidine 5 -phosphotransferase thymidine phosphotransferase 

115 (Protein kinases are in a state of review by the NC-IUBMB. This EC class will presumably be transferred to EC 2.7.11.4) 

Additional information 2 ( 2 kinase activity is an intrinsic activity of branched-chain oxo acid dehydrogenase complex [3]) [3] 

ATP -I- [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] = ADP -I- [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate 

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Labenz, J. Muller, W.E.G. Falke, D. Inhibition of the Herpes simplex virus-coded thymidine kinase-complex by 9- -D-arabinofuranosyladenine 5-monophosphate (ara-AMP) and 9-(2-hydroxyethoxymethyl)guanine-mono-phosphate (acyclo-GMP). Arch. Virol., 81, 205-212 (1984)... 

Thus, uridine-cytidine kinase converts uridine and cytidine to UMP and CMP, respectively thymidine kinase converts thymidine to dTMP and adenosine kinase converts adenosine to AMP. Specific kinases convert monophospho-nucleotides to dinucleotides using ATP as a phosphate donor. The conversion of diphosphonucleotides to triphosphonucleotides is carried out by a nonspecific nucleoside diphosphate kinase. This includes both the ribo- and deoxy-ribonucleotides. Cytosine and its nucleoside and nucleotide transformations are often associated with the metabolism of uracil and its nucleosides and nucleotides. Note that UTP can give rise to CTP (Figure 10.9), and also that, in the presence of cytidine deaminase, cytidine can be converted to uridine. 

In the area of 3, 5 -cyclic nucleotides, it has been found that attempted 5 -phosphorylation of the 3 -epimers of thymidine and deoxyadenosine with phosphoryl chloride gave the cyclic phosphates 195 (B = Ad, T) the 5 -phosphates could be obtained by phosphorylation of the 3 -0-benzoyl derivatives.245 Two groups have reported the synthesis of base-modified derivatives of c AMP (e.g. benzimidazoles, benzotriazoles, indazoles), for evaluation as activators of cAMP-dependcnt protein kinase 1.246,247 There have been syntheses described of ribonucleoside 3 ,5 -cyclic methyl- and phenyl-phosphonates248,249 and -phosphonothioates, one of the procedures giving both the cyclic phosphonates and phosphonothioates as the 5p-epimer only.249 a paper... 

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