AMP-dependent protein kinase in the adrenal cortex

Cyclic AMP-dependent protein kinase in the adrenal cortex 

Both type I and type II cyclic AMP-dependent protein kinase forms are found in the adrenal cortex [8]. The predominant form in the Y1 adrenocortical tumor cell line is type I [2], Yl(Kin) mutants with RI subunits which have a much lower affinity for cyclic AMP lack ACTH-stimulated cyclic AMP production, thus demonstrating the involvement of the type I form of cyclic AMP-dependent protein kinase in the action of ACTH. 

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