Amoxicillin-clavulanate adverse effects

In patients with significant bacteriuria, symptomatic or asymptomatic, treatment is recommended in order to avoid possible complications during the pregnancy. Therapy should consist of an agent with a relatively low adverse-effect potential (a sulfonamide, cephalexin, amoxicillin, amoxicillin/clavulanate, nitrofurantoin) administered for 7 days. 

Therapy should consist of an agent administered for 7 days that has a relatively low adverse-effect potential and is safe for the mother and baby. The administration of a sulfonamide, amoxicillin, amoxicillin-clavulanate, cephalexin, or nitrofurantoin is effective in 70% to 80% of patients. Tetracyclines should be avoided because of teratogenic effects, and sulfonamides should not be administered during the third trimester because of the possible development of kernicterus and hyperbilirubinemia. In addition, the available fluoroquinolones should not be given because of their potential to inhibit cartilage and bone development in the newborn. A follow-up urine culture 1 to 2 weeks after completing therapy and then monthly until gestation is complete is recommended. 

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