Amox - Amoxicillin

Figure 1.9 [18] illustrates the use of CE for the analysis of amoxicillin (AMOX) from various suppliers. Unidentified impurities (1 and 2) and degradant (DG) are seen, and the mixtures are spiked with ampicillin (AMP) and penicillin V (PENV). 

Figure 1.9 Use of capillary electrophoresis for the analysis of amoxicillin from four suppliers (a-d). Reprinted from [18], copyright 1994, with permission from Elsevier. (AMOX is amoxicillin, AMP is ampicillin, PENV is penicillin V, DG is a degradant, and 1 and 2 are unspecified impurities. Capillary 80 cm X 50 (tm i.d. [75 cm to detector] [Polymicro Technologies] running buffer 100 mM pH 8 Na2HP04 containing 50 mM sodium dodecyl sulfate and 50 mM sodium borate voltage 18 kV injection at 100 mm for 15 s detector UV 205 nm.)...

MSSA means methicillin-sensitive Staphylococcus aureus. M. and E. mean Micrococcus and Escherichia, respectively. A positive control used was amoxicillin (AMOX). ND, not determined. 

Positive control clarithromycin (=CLAR) and amoxicillin (=AMOX). 

U.S. Food and Drug Administration. (2001b). Commentary on non-labeled dosing of oral amoxicillin in adults and pediatrics for post-exposure inhalational anthrax. U.S. Food and Drug Administration Center for Drug Evaluation and Research. Retrieved March 13, 2007 from http //www.fda.gov/cder/ drugprepare/amox-anthrax.htm... 

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