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Amonafide acetylation

Due to the polymorphic acetylation of amonafide, a phenotyping procedure for amonafide acetylation using caffeine as a probe was evaluated in cancer patients. Slow and fast acetylators of both caffeine and amonafide were identified. Fast ace-... [Pg.296]

Dose Individualization of Amonafide Based on N-Acetylator Phenotype... [Pg.296]

Fig. 14.9 Degree of leukopenia in cancer patients receiving amonafide. Incidence and degree of leukopenia was higher in fast acetylators compared to slow acetylators. Fig. 14.9 Degree of leukopenia in cancer patients receiving amonafide. Incidence and degree of leukopenia was higher in fast acetylators compared to slow acetylators.
Ratain MJ, Mick R, Berezin F et al. Phase I study of amonafide dosing based on acetylator phenotype. Cancer Res 1993 53 2304-2308. [Pg.307]

Ratain MJ, Mick R, Janish L et al. Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender. Pharmacogenetics 1996 6 93-101. [Pg.307]

See other pages where Amonafide acetylation is mentioned: [Pg.296]    [Pg.296]    [Pg.296]    [Pg.296]    [Pg.297]    [Pg.152]    [Pg.251]    [Pg.732]    [Pg.1609]   
See also in sourсe #XX -- [ Pg.296 ]



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Amonafide

Dose Individualization of Amonafide Based on N-Acetylator Phenotype

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