Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Amonafide

Dose Individualization of Amonafide Based on N-Acetylator Phenotype... [Pg.296]

Due to the polymorphic acetylation of amonafide, a phenotyping procedure for amonafide acetylation using caffeine as a probe was evaluated in cancer patients. Slow and fast acetylators of both caffeine and amonafide were identified. Fast ace-... [Pg.296]

Fig. 14.9 Degree of leukopenia in cancer patients receiving amonafide. Incidence and degree of leukopenia was higher in fast acetylators compared to slow acetylators. Fig. 14.9 Degree of leukopenia in cancer patients receiving amonafide. Incidence and degree of leukopenia was higher in fast acetylators compared to slow acetylators.
Felder TB, McLean MA, Vestal ML et al. Pharmacokinetics and metabolism of the antitumor drug amonafide (NSC-308847) in humans. Drag Metab Dispos 1987 15 773-777. [Pg.307]

Ratain MJ, Mick R, Berezin F et al. Paradoxical relationship between acetyla-tor phenotype and amonafide toxicity. [Pg.307]

Clin Pharmacol Ther 1991 50 573-579. Ratain MJ, Rosner G, Allen SL et al. Population pharmacodynamic study of amonafide a Cancer and Leukemia Group B study J Clin Oncol 1995 13 741-747. [Pg.307]

Ratain MJ, Mick R, Janish L et al. Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender. Pharmacogenetics 1996 6 93-101. [Pg.307]

Innocent E, Iyer L, Ratain MJ. Pharmacogenetics of anticancer agents Lessons form amonafide and irinotecan. Drug Met. Disp. 2001 29 596-600. [Pg.1933]

N-acetyltransferase (NAT2) Isoniazid, hydralazine, sulfonamides, amonafide, procainamide, dapsone, caffeine Hypersensitivity to sulfonamides, amonafide toxicity, hydralazine-induced lupus, isoniazid neurotoxicity... [Pg.65]

See other pages where Amonafide is mentioned: [Pg.283]    [Pg.296]    [Pg.296]    [Pg.296]    [Pg.296]    [Pg.296]    [Pg.296]    [Pg.297]    [Pg.152]    [Pg.364]    [Pg.251]    [Pg.732]    [Pg.14]    [Pg.15]    [Pg.181]    [Pg.205]    [Pg.1605]    [Pg.1609]    [Pg.1610]    [Pg.379]    [Pg.379]    [Pg.53]    [Pg.1467]    [Pg.364]   


SEARCH



Amonafide acetylation

Dose Individualization of Amonafide Based on N-Acetylator Phenotype

© 2024 chempedia.info