Sildenafil Amlodipine

The effect of sildenafil on arterial pressure has been tested in 16 hypertensive men taking amlodipine 5-10 mg/day (23). Sildenafil did not affect amlodipine pharmacokinetics, but caused a further additive fall in blood pressure. Adverse events with the combination of sildenafil and amlodipine, headache, dyspepsia, and nausea, did not require drug withdrawal. 

Hypertensive patients taking amlodipine, in contrast to glyceryl trinitrate, had only a minor supplementary fall in blood pressure when challenged with a single dose of sildenafil, and a few had a mild to moderate headache (46). 

Potentiation by sildenafil of the hypotensive effects of glyceryl trinitrate and amlodipine has been investigated. The fall in systolic blood pressure with glyceryl trinitrate was amplified four-fold by sildenafil in healthy subjects. 

Mexiletine Progesterone Testosterone Sildenafil Trazodone Vineristine Zaleplon Zolpidem Amlodipine Diltiazem Nifedipine Verapamil... 

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