Amlodipine hypotension caused

Of the CCBs, the nondihydropyradines (verapamil and dilti-azem) are the most effective because they lower heart rate in addition to lowering blood pressure. Nifedipine, because of its strong vasodilator properties, tends to cause hypotension and reflex tachycardia. In addition, nifedipine causes peripheral edema. These characteristics make it less useful in DHR Amlodipine is also effective because it reduces blood pressure. Initial doses are verapamil 120 to 240 mg/day, diltiazem 90 to 120 mg/day, and amlodipine 2.5 mg/day. 

There is evidence that most NSAIDs can increase blood pressure in patients treated with antihypertensives, although some studies have not found the increase to be clinically relevant. In various small studies, indometacin appeared not to reduce the hypotensive effects of amlodipine, felodipine, nicardipine, nimodipine or verapamil, but it did in one of two studies with nifedipine, and one study with nitrendipine. Similarly, ibuprofen caused a small reduction in the antihypertensive effects of amlodipine. Diclofenac and sulindac appear not to interact with nifedipine, nor ibuprofen, naproxen, piroxicam or sulindac with verapamil, nor naproxen with nicardipine. Low-dose aspirin did not alter the antihypertensive effect of felodipine or nifedipine in one study, and long-term aspirin did not alter the cardiovascular benefits of nitrendipine in another. Diclofenac reduces verapamil serum levels and raises those of isradipine, but these changes are probably unimportant. 

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