Amlodipine dosage

Dosage Dose should be individualized by titration 180 mg/d with upward titrations if adequate response is not obtained Dose should be individualized 5 mg/d with a maximum dose of 10 mg/d Dose should be individualized by titration 2.5 mg to 5 mg amlodipine and 10 mg to 20 mg of benazepril once daily... 

A. Abdoh, M. M. Al-Omari, A. A. Badwan, A. M. Y. Jaber, Amlodipine besylate— excipients interactions in solid dosage form, Pharm. Dev. Technol. 9 (2004), 15-24. 

While that particular combination isn t currently on the market, one product (Caduet) combines Lipitor (atorvastatin) for cholesterol lowering and Norvasc (amlodipine) for blood pressure reduction. Caduet is available in a wide variety of dosages of both agents, allowing physicians to choose the one that would best suit a particular patient. That s much better than a fixed combination, since typically one size does not fit all. 

There are approximately a dozen calcium channel antagonists marketed in the United States for the treatment of hypertension, certain dysrhythmias, and some forms of angina (see Chaps. 13,15, and 17). The calcium channel blockers are classified by their chemical structure as phenylalkylamines (e.g., verapamil), benzothiapines (e.g., diltiazem), and dihydropyridines (e.g., amlodipine, felodipine, nicardipine, and nifedipine). Several of these agents, namely, diltiazem, nicardipine, nifedipine, and verapamil, are formulated as sustained-release oral dosage forms or have a slow onset of action and longer half-life (e.g., amlodipine " ), allowing once-daily administration. 

Information about the effects of calcium-channel bloekers on ear-bamazepine is limited, but what is known indicates that if carbamazepine is given with verapamil or diltiazem, the carbamazepine dosage may possibly need to be reduced to avoid toxicity. A 50% reduction in the dose of carbamazepine has been suggested if diltiazem is to be used. Nifedipine and amlodipine normally appear to be non-interaeting alternatives. Oxear-bazepine appears to be a non-interaeting alternative for carbamazepine. 

The manufacturers say that amlodipine has been safely given with thiazide diuretics and no dosage adjustment of amlodipine is required. Additive antihypertensive effects are expected when diuretics such as hydrochlorothiazide are used in combination with calcium-channel blockers, and such combinations are used clinically. 

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