Enflurane Amitriptyline

Clozapine Fluoxetine Amitriptyline Antidepressants Enflurane Antidepressants... 

Amitriptyline may potentiate enflurane-induced cerebral irritability (19). 

Tricyclic antidepressants may increase the risk of arrhythmias and hypotension during anaesthesia. Tachyarrhythmias have been seen in patients taking imipramine who were given halothane and pancuronium. Some very limited evidence su ests that amitriptyline may increase the likelihood of enflurane-induced seizure activity. A man taking maprotiline and lithium developed a tonic-clonic seizure when given propofol. Tricyclics may cause an increase in the duration of barbiturate anaesthesia and lower doses of barbiturates may be required. 

Sprague DH, Wolf S. Enflurane seizures in patients taking amitriptyline. AnesthAnalg (1982) 61,67-8. 

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