Disulfiram Amitriptyline

Primidone Disulfiram Dextroamphetamine Valproic acid Phenylephrine Phenytoin Isoetharine Carbamazepine Amitriptyline Triazolam Diazepam... 

Maany I, Hayashida M, Pfeffer SL, Kron RE. Possible toxic interaction between disulfiram and amitriptyline. Arch Gen Psychiatry 1982 39(6) 743. ... 

Buspirone does not appear to interact with amitriptyline, cimetidine or terfenadine. An isolated report describes mania when an alcoholic patient taking huspirone was given disulfiram. Nefazodone greatly increases huspirone levels. 

It has been noted that amitriptyline increases the effects of both disulflram and citrated calcium carbimide without any increase in adverse effeets. However, there is also some evidence that an adverse interaction can occur. A study in two men found that disulfiram 500 mg daily increased the AUC of imipramine (12.5 mg given intravenously after an overnight fast) by about 30%, and of desipramine 12.5 mg given intravenously in one subject by a similar amount. Peak plasma levels were also increased. The suggest reason is that the disulfiram inhibits the metabolism of the antidepressants by the liver. There is also a report of a man taking disulfiram who, when given amitriptyline, complained of dizziness, visual and auditory hallucinations, and who became disorientated to person, plaee and time. A similar reaction was seen in another patient. Concurrent use should therefore be well monitored for any evidence of toxicity. 

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