Amiodarone Coumarins

Maintenance doses widely vary among patients (e.g., from 1 to 20 mg/day for warfarin), and are influenced by diet (variable vitamin K intake) and medications that affect coumarin metabolism (decreased drug clearance e.g., cotrimoxazole, amiodarone, erythromycin increased clearance e.g., barbiturates, carbamaze-pine, rifampin). Thus, regular monitoring is needed... [Pg.109]

Cardiovascular Acetyldigosin, ajmaline, amiodarone, aprindine, bepridil, bezaflbrate, captopril, dinepazide, clopidogrel, coumarins, diazoxide, digoxin, dipyridamole, disopyramide, doxazosin, enalapril, flurbiprofen, fur-oxemide, hydralazine, lisinopril methyldopa, metolazone, nifedipine, phenindione, procainamide, propanolol, propafenone, quinidine, ramapril, spironolactone, thiazide diuretics, ticlopidine, vesnarinone... [Pg.416]

Figure 17.4 Compounds which are mentioned throughtout the chapter and numbered in the main text as follows (1) DMZ, (2) diclofenac, (3) flurbiprofen, (4) warfarin, (5) fluconazole, (6) coumarin, (7) dapsone, (8) retinoic acid, (9) arachidonic acid, (10) troglitazone, (11) fluvastatin, (12) cerivastatin, (13) taxol, (14) gemfibrozil, (15) verapamil, (16) amodiaquine, (17) amiodarone, (18) metyrapone, (19) progesterone, (20) testosterone, (21) erythromycin, (22) ketoconazole, (23) nicotine, (24) IV -Nitrosonor-nicotine, (25) 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone...

Amiodarone inhibits the metabolism of warfarin, probably because it, and/or its metabolite desethylamiodarone, inhibit the cytochrome P450 isoenzyme CYP2C9, CYP3A4 and CYP1A2 (see metabolism of the coumarins , (p.358)). [Pg.363]

Thyrotoxicosis, which can be caused by amiodarone, potentiates the effect of warfarin, see Coumarins and related drugs + Thyroid and Antithyroid compounds , p.455. As a result less warfarin would be required to prolong the prothrombin time. - ... [Pg.363]

Similar advice applies to acenocoumarol and phenprocoumon, and probably also other coumarins. Some recommend an initial reduction in acenocoumarol dose of 50% when amiodarone is added, whereas others recommend that the INR should be closely monitored, and the dose of acenocoumarol only reduced in response to an increase in INR. ... [Pg.363]

Bharat V, Mohanty B. Bleeding complication during coumarin tiierapy due to amiodarone and azithromycin. J Assoc Physicians India (2000) 48,746-7. [Pg.364]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...