Aminophosphine-Phosphinites AMPPs

In general, applications of AMPP have concentrated on the asymmetric hydrogenation of functionalized olefins, especially dehydroamino acids. Among 

Copyright 2007 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-31161-3 

Entry Substrate Catalyst Conditions TON TOF [h-1] Conv. [%] ee [%] Refer- ence ) 

886 27 Bidentate Ligands Containing a Heteroatom-Phosphorus Bond 

---

Table 27.1 Enantiomeric hydrogenation using aminophosphine-phosphinites (AMPP). 

Chiral ligands containing tervalent phosphorus acid derivatives as coordination sites continue to be explored for asymmetric metal catalysed reactions. New examples this year include the phosphite (119) and stereoisomers, the phosphites (120), 2 the diphosphinite TADDOP (121), the diphosphites (122) containing crown ethers, the aminophosphine-phosphinites AMPP s (123) and... 

Aminophosphine phosphinite (AMPP) ligands constitute an important class of non-C2 diphosphorus ligands. Some of them are prepared from ephedrine and therefore the Juge-Stephan method constitutes an ideal procedure for the synthesis of P-stereogenic AMPP ligands (Scheme 4.30). ... 

Also, aminophosphine-phosphinites 1 (AMPPs), originally developed as ligands for asymmetric hydrogenation by the Lyon group of Agbossou-Niedercorn and Mortreux [47, 48], have been tested in asymmetric hydroformylation with a tin-free Pt catalyst (Pigure 1.13). 

---