Aminopeptidase discovery

Found to be subject to metal ion catalysis, but the discovery by Kroll in 1952 that the hydrolysis af a-amino acid esters was catalyzed by metal ions stimulated considerable interest in the area. Many of these reactions can be considered as simple model systems for such metalloenzymes as arboxypeptidase A, leucine aminopeptidase and glycylglycine dipeptidase.25... 

Sheppard, G.S., et al. Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 A structural basis for the reduction of albumin binding. J. Med. Chem. 2006, 49, 3832-3849. The authors note that improvements in cellular antiproliferative potency may have involved other factors besides just protein binding. 

Discovery of D-Stereospecific Aminopeptidase and its Utiiization for Dynamic Kinetic Resolution... 

Discovery of D-Aminopeptidase, D-Amino Acid Amidase, and Alkaline o-Peptidase... 

---