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Aminopenicillins dimerization

Polymerisation is the process by which two or more identical dmg molecules combine together to form a complex molecule. It has been demonstrated that a polymerisation process occurs during the storage of concentrated aqueous solutions of aminopenicillins, such as ampicillin sodium. The reactive j3-lactam bond of the ampicillin molecule is opened by reaction with the side-chain of a second ampicillin molecule and a dimer is... [Pg.102]

Table 2. Rate constants for the dimerization of aminopenicillins in aqueous solution at 35 °C and ionic strength 1.0. (Bundgaard 1977 b)... Table 2. Rate constants for the dimerization of aminopenicillins in aqueous solution at 35 °C and ionic strength 1.0. (Bundgaard 1977 b)...
In considering structural factors influencing the rate of dimerization of aminopenicillins and possibly accounting for the observed differences in the rates, account must be taken of (1) the susceptibility of the j5-lactam moieties to attack by... [Pg.50]

Table 4. Relative rates of dimerization of some aminopenicillins in aqueous solution, pH 9.0 35 °C concentration range 0.05-0.6 M. (Bundgaard 1977b)... Table 4. Relative rates of dimerization of some aminopenicillins in aqueous solution, pH 9.0 35 °C concentration range 0.05-0.6 M. (Bundgaard 1977b)...
See other pages where Aminopenicillins dimerization is mentioned: [Pg.47]    [Pg.50]    [Pg.51]    [Pg.54]    [Pg.54]    [Pg.68]   
See also in sourсe #XX -- [ Pg.48 , Pg.50 , Pg.51 ]



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Aminopenicillins

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