Aminoindoline scaffold

With the goal of producing different indoline-based functionalized polycyclic architectures and using such architectures in library generation, we developed a practical, enantio-controlled synthesis of an aminoindoline scaffold, (14) (Figure 17.7) [26]. This scaffold has several attractive features that make it extremely... 

Fig. 17.13 The use oftetrahydroaminoquinoline and aminoindoline scaffolds in the library generation of natural product-like compounds and in silico testing of these two libraries as small molecule binders to Bcl-2/Bcl-XL...

Gan, Z., Reddy, P. T, Quevillon, S., Couve-Bonnaire, S., Arya, P. (2005) StereocontroDed solid-phase synthesis of a 90-member library of indohne-alkaloid-like polycyclics from an enantioriched aminoindoline scaffold. Angewandte Chemie, International Edition, 44, 1366-1368. 

Solution- and solid-phase, modular approaches for obtaining different natural product-hke polycyclic architectures from an aminoindoline scaffold for combinatorial chemistry. Journal of Combinatorial Chemistry, 8, 856-871. 

Gan Z, Reddy PT, Quevillon S, Couve-Bonnaire S, Arya P. Stereocontrolled solid-phase synthesis of a 90-membered library of indoline-alkaloid-like polycycles from an enan-tioenriched aminoindoline scaffold. Angew. Chem. Int. Ed. 2005 44 1366-1368. 

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