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Aminoimidazolecarboxamide ribonucleotid

Methotrexate s principal mechanism of action at the low doses used in the rheumatic diseases probably relates to inhibition of aminoimidazolecarboxamide ribonucleotide (AICAR) transformylase and thymidylate synthetase, with secondary effects on polymorphonuclear chemotaxis. There is some effect on dihydrofolate reductase and this affects lymphocyte and macrophage function, but this is not its principal mechanism of action. Methotrexate has direct inhibitory effects on proliferation and stimulates apoptosis in immune-inflammatory cells. Additionally, inhibition of proinflammatory cytokines linked to rheumatoid synovitis has been shown, leading to decreased inflammation seen with rheumatoid arthritis. [Pg.808]

Aminoimidazole ribonucleotide (AIR) Aminoimidazolecarboxylate ribonucleotide (CAIR) Aminoimidazole succinocarboxamide ribonucleotide (SAICAR) Aminoimidazolecarboxamide ribonucleotide (AICAR) Formamidoimidazolecarboxamide ribonucleotide (FAICAR)... [Pg.101]

Figure 2 Physiology and metabolism of folate. GAR, glycinamide ribonucleotide FGAR, formylglycinamide ribonucleotide AlCAR aminoimidazolecarboxamide ribonucleotide figlu, formiminoglutamic acid IMP, inosine monophosphate. Figure 2 Physiology and metabolism of folate. GAR, glycinamide ribonucleotide FGAR, formylglycinamide ribonucleotide AlCAR aminoimidazolecarboxamide ribonucleotide figlu, formiminoglutamic acid IMP, inosine monophosphate.
See other pages where Aminoimidazolecarboxamide ribonucleotid is mentioned: [Pg.318]    [Pg.318]    [Pg.727]   
See also in sourсe #XX -- [ Pg.308 ]



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