Aminoglycosides structural relationship between

Pfister, P., Hobbie, S., Vicens, Q., Bottger, E.C., Westhof, E. The molecular basis for A-site mutations conferring aminoglycoside resistance Relationship between ribosomal susceptibility and X-ray crystal structures. ChemBioChem 2003, 4(10), 1078. 

The discovery of Gentamydn and its successful utilisation for the treatment of serious gram-negative infections has contributed in the last years to increasing clinical use and to a rapid development of the chemistry and biochemistry of aminoglycoside antibiotics. Also of importance in the further exploration of this class of compounds are the new chemical and physico-chemical methods, e.g. H- and C-NMR-spectroscopy, mass spectroscopy. X-ray analysis and the different chromatographic methods. Synthetic efforts and studies of the inactivation mechanism have provided a preliminary insight into the relationship between structure and activity. 

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