Aminoglycosides Pyranmycin

Designs involving disaccharide have also been attempted (Fignre 4.5). However, disaccharide-based aminoglycosides are less active in general. For example, the designs of 45 and 46 that mimic rings 11 and 111 of pyranmycin were found to be inactive. 

Copyright (2005) from (Novel Method for the Synthesis of 3, 4-Dideoxygenated Pyranmycin and Kanamycin Compounds, and Studies of Their Antibacterial Activity against Aminoglycoside Resistant Bacteria) by (Cheng-Wei Tom Chang). Reproduced by permission of Taylor Francis Group. LLC., http//www.taylorandfrancis.com. 

The constructed N-1 modified pyranmycin was assayed against aminoglycoside susceptible and resistant strains of Escherichia coli using ribostamycin, and butirosin as the controls. From the MIC values, the synthesized aminoglycoside with the attachment of AHB group at N-1 regain the activity against both resistant strains of bacteria (Table III). 

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