Aminoglycosides drug related

Patients treated for intraabdominal infections should be assessed for the occurrence of drug-related adverse effects, particularly hypersensitivity reactions (/ -lactam antimicrobials), diarrhea (most agents), fungal infections (most agents), and nephrotoxicity (aminoglycosides). 

As with other cases of ARF, ARF due to drugs is most often the consequence of multiple simultaneous insults. For example, Rasmussen and Ibels [4] found that 62% of 143 patients had more than one acute insult, including excessive aminoglycoside exposure and radiocontrast material administration. In the series of Davidman et al, [14], multiple causes of ARF were also present in 50% of 38 patients with drug-related renal disease. 

D Disturbed Sensory Perception Auditory related to adverse drug readions ot the aminoglycosides... 

Spectinomycin (Trobicin) is chemically related to but different from the aminoglycosides (see Chap. 10). This drug exerts its action by interfering with bacterial protein synthesis. Spectinomycin is used for the treatment of gonorrhea... 

Do not use tuberculosis regimens consisting of isoniazid, ethambutol, and pyrazinamide (ie, 3-drug regimens that do not contain a rifamycin, an aminoglycoside [eg, streptomycin, amikacin, kanamycin], or capreomycin) for the treatment of patients with HIV-related tuberculosis. The minimum duration of therapy is 18 months (or 12 months after documented culture conversion) if these regimens are used for the treatment of tuberculosis. 

---