Aminoglycoside-Specific Lymphocyte Reactivity

Lymphocyte transformation tests have been carried out be many researchers using streptomycin (Vischer 1966 Halpern et al. 1967 Sarkany 1967 Mathews et al. 1972) and/or the other aminoglycosides (Halpern et al. 1967 Sarkany 1967 Muhlberger 1973 Warrington et al. 1979). A significant proliferation response. 

The direct inhibition of leukocyte migration has been used to evaluate patients with adverse reactions to neomycin (Nordquist and Rossmann 1967) and in five of seven patients significant inhibition was demonstrated. 

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