Aminoglycoside derivatives antibiotics binding

Williams, P.D., Hottendorf, G.H. and Bennett, D.B. (1986a). Inhibition of renal membrane binding and nephrotoxicity of aminoglycosides. J. Pharmacol. Exp. Ther. 237 919-925. Williams, P.D., Laska, D.A. and Hottendorf, G.H. (1986b). Comparative toxicity of aminoglycoside antibiotics in cell cultures derived from human and pig kidney. In Vitro Toxicol. 1 23-32. 

The neamine-derived aldehyde 81 has been prepared and used in combinatorial synthesis of a library of neomycin B mimetic aminoglycoside antibiotics, a strategy for the discovery of new inhibitors for binding to the Rev-responsive element of HIV mRNA [55], The synthesis involves allylation of the selectively protected neamine derivative 80, followed by ozonolysis of the allylic double bond to generate the aldehyde functional group (compounds 80, 81). 

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