AMINOALCOHOLS AND DERIVATIVES

Reagents that encompass both the alcohol and the amine functional groups of a commercially available aminoalcohol are very usefirl. Ephedrine 1.61 (R = Me), pseudoephedrine 1.78, norephedrine 1.61 (R=H) and their Aralkyl and N-acyl derivatives are commonly used, [253, 290, 320-324], as are aminoalcohols 1.79. Also popular are aminoalcohols formed from the natural aminoadds (S)-alaninol 

The reactions of 1,2-aminoalcohols 1.60 (R = i-Pr, tert-Bu, Ph, R = H) or 1.79 (R = H) with y- or 6-ketoacids generate chiral bicyclic lactams 1.90 and 1.91. The chemistry of this class of reagents has also been developed by Meyers and coworkers [261, 327, 348], and another access to these compounds has also been proposed [327], 

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