Amino Terminal Domain Structures and Structural Motifs

Amino Terminal Domain Structures and Structural Motifs 

Cofactor proteins bind both the proteinase (enzyme) and the proenzyme (substrate). They bind to lipid membranes. 

Proteinase inhibitors (proteins) that circulate in plasma inactivate the hemostatic system proteinases after they have essentially completed their proteolyses. With two exceptions, o 2-niacroglobulin and tissue factor pathway inhibitor, all of the inhibitors of the procoagulant, anticoagulant, and fibrinolytic proteinases are SERPINS 

The reaction of the proteinase with the inhibitor occurs at a basic residue (Arg or Lys residue) in a loop that extends away from the globular inhibitor molecule. This basic residue, called the reactive site residue, is locked in the proteinase active site as the acyl enzyme. The reactive site 

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