2-Amino-977-pyrido- indole

Amino-9//-pyrido[3,4-6]indoles 87MIP4, 87MIP5 88IJC(B)484... 

Figure 13.7 Mutagenic and carcinogenic heterocyclic amines of the carboline group (a) AaC (2-amino-9//-p5Tido[2,3,-i)]indole), (b) norharman (9f/-pyrido[4,3-i)]indole), (c) Trp-P-1 (3-amino-l,4-dimethyl-57/-pyrido[4,3-/)]indole), (d) Glu-P-1 (2-amino-6-methyl-dipyrido[l,2-a 3, 2 -d]imidazole).

Z-aminO 1 -methy 1 6 phenylimidazo [4,5-b]-pyridine 2 aminO 3,7,8 trimethylimidazo[4,5 f]quinoxaline 2 aminO 3,4,7,8 tetramethyl 3H imidazO [4,5 f]quinoxaline inoxaline 3 aminO l,4 dimethyl SH pyrid [4,3 b] indole (Trp P I) and 3 aminO l methyl 5H pyrido [4,3 b]indole induced mutagenesis. Metabolic activation was required for positive results b... 

Amino-l-methyl-527-pyrido[4,3-6]indole (see Trp-P-2) 2-Amino-5-(5-nitro-2-furyl)-l,3,4-thiadiazole 2-Amino-4-nitrophenol 2-Amino-5-nitrophenol... 

Amino-2-nitrophenol 2-Amino-5-nitrothiazole 2-Amino-9A-pyrido[2,3-i]indole (see A-a-C)... 

DiMeIQx 2-amino-3,4,8-trimethylimidazo-[/] quinoxaline nh2 Trp-P-1 3-amino-l,4-dimethyl-5H-pyrido[4,3-/)Jindole CH3 0X1. CH3 Trp-P-2 3-amino-l-methyl-5H-pyrido[4,3-/)]indole ch3 f S X" N... 

AaC 2-amino-9H-pyrido[2,3- Z>]indole MeAaC 2-amino-3-methyl-9H-pyrido[2,3-/>] indole CtXX" Glu-P-l amino-6-methyl dipyrido-[ 1,2-a 3 , 2 - imidazole (X N—XvNH2 CH3... 

PhIP 2-amino-l-methyl-6-phenylimidazo[4,5-/)]pyridine n T Vnh2 Nr" harman 1 -methyl-9H-pyrido[4,3-b]indole O7O ch3 norharman 9H-pyrido[4,3-b]indole v. L Jj... 

Galceran et al. (199) developed an SPE-HPLC method for the determination in beef extract of five mutagenic amines, namely Trp-P-1 (3-amino-1,4-dimethyl-5//-pyrido[4,3-fc]indole),... 

Trp-P-2 (3-amino-l-methyl-5//-pyrido[4,3-h]indole), AaC (2-amino-9//-pyrido[2,3-bJindole), MeAaC (2-amino-3-methyl-9//-pyrido[2,3- ]indole), and PhIP (2-amino-1-methyl-6-phenyl-imidazo[4,5-h]pyridine) and two /3-carbolines comutagens harman (l-methyl-9//-pyrido[4,3-h]indole) and norharman (9//-pyrido[4,3-h]indole). The optimized SPE procedure for isolation and preconcentration comprises the use of diatomaceous earth, propylsulfonyl silica gel, and C18 cartridges to separate selectively the imidazopyridine and indolpyridine derivatives from those of... 

Yoshida et al (25) Isolated 2-amino-91/-pyrIdo[2,3- ]Indole (AcxC) and 2-amino-3-me thy l-9 -pyrido[ 2,3-b ] indole (MeActC) from pyrolysate of soybean globulin. 

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