4-Amino-3-nitrobenzophenone

Amino-5-bromophenyl(pyridin-2-yl)methanone ( ABP , deep violet, hR < 5), 2-amino-5-nitrobenzophenone ( ANB , pink, hR 15 — 20), 2-amino-5-chloro-... 

Disposition in the Body. Readily absorbed after oral administration. The major metabolites, 7-aminonitrazepam and the 7-acetamido derivative accumulate to some extent in plasma. Other metabolites include 2-amino-5-nitrobenzophenone and 2-amino-3-hydroxy-5-nitrobenzophenone all the metabolites are inactive. After oral administration, about 50 to 70% of a dose is excreted in the urine in 120 hours and up to 20% is eliminated in the faeces. Up to about 37% of a dose may be excreted in the... 

Scheme 4.13 Simplified decomposition scheme for nitrazepam (VI) in the solid state and aqueous solution. The main decomposition product is 2-amino-5-nitrobenzophenone (VII) in aqueous solution and 3

Also obtained (by-product) by diazotization of 2-amino-5-nitrobenzophenone (4%). The 2-nitrofluorenone was the major compound obtained (75%) [539]. Also obtained (poor yield) by Fries rearrangement of p-nih Ophenyl benzoate with aluminium chloride in nitrobenzene at 170° for 1 h (4%) [540]. Preparation from 2-nitrothioxanthen-9-one 10,10-dioxide (SM) by a three-step synthesis SM by refluxing in a solution of 2% sodium hydroxide in dioxane/ water mixture (65 35) for 2 h, gave the 2-(2-hydroxy-5-nitrobenzoyl)phenyl-sulfmic acid (89%). The former by reaction with mercuric chloride in refluxing aqueous acetic acid for 4 h led to the 2-chloromercuri-2 -hydroxy-5 -nitro-benzophenone (82%). Removal of the chloromercury group was achieved with concentrated hydrochloric acid in refluxing ethanol for 2 h (84%) [62]. 

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