5-Amino-n-valeric acid

Amino-n-valeric acid hydrochloride [627-95-2] M 153.6, m 103-104 . Crystd from CHCI3. 

Amino-n-valeric acid hydrochloride [627-95-2] M 153.6, m 92-94", 103-104". Crystallise the salt from CHCI3. Otherwise dissolve it in EtOH and add 2 volumes of Et20 and chill. [Schniepp Marvel J Am Chem Soc 57 1557 1935, Woods Colver J Am Chem Soc 67 654 1945, Beilstein 4 III 1343, 4 IV... 

The best method for the preparation of A-alkylamide peptides employs 5-(4- [[(9//-fluoren-9-ylmethoxy)carbonyl](alkyl)amino]methyl -3,5-dimethoxyphenoxy)valeric acid [(R)-PAL handle, 29],f l which is derived from the PAL handle. The (R)PAL handle, when used in the same way as PAL, would transfer the alkylamine to the peptide. Similarly, the use of N-alkyl XALP 1 or A-alkyl Rink resinst °°l also gives rise to A-alkylamide peptides. The same conditions as those used to release peptides from PAL, Rink, and XAL apply for the A-alkyl analogues. The preparation of A/,A-dialkylamide peptides requires a backbone attachment strategy (see Section 4.3.1.2.5).f l... 

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