Amino ketone hydrochloride

Cp,Cp-IndoNOP 18 [15 p], have provided excellent enantioselectivity and reactivity for the enantioseiective hydrogenation of a-, / -, and y-alkyl amino ketone hydrochloride salts. 

Amino Ketones Amino ketones and their hydrochloride salts can be effectively hydrogenated with chiral rhodium catalysts (Tab. 1.9). The rhodium precatalysts, combined with chiral phosphorous ligands such as BPPFOH [10b], MCCPM [24f-k], Cy,Cy-oxo-ProNOP [79c, e], Cp,Cp-oxoProNOP [79c, e], and IndoNOP [79g], have provided excellent enantioselectivity and reactivity for the asymmetric hydrogenation of a, yS, and y-al-kyl amino ketone hydrochloride salts. 

SL 358 (1995) (a-keto lactone and amide, a-amino ketone hydrochloride)... 

The two-step one-pot total synthesis of Ro 22-1319, an antipsychotic agent featuring a rigid pyrrolo[2,3-g]isoquinoline skeleton, was accomplished by D.L. Coffen and co-workers. The cyclic 1,3-diketone precursor was prepared from arecoline and dimethyl malonate, and in the same reaction vessel an amino ketone hydrochloride was added. The pH of the reaction mixture was adjusted to 4 in order to initiate the formation of the pyrrole. 

This reaction has been modified by directly using a-amino ketone hydrochloride or reducing a-nitrosoketone or hydrazone via hydrogenation to form pyrrole derivatives. 

Later, these authors extended this methodology to the hydrogenation of substituted aromatic a-amino ketone hydrochlorides by using the same... 

Hydrogenation of substituted aromatic a-amino ketone hydrochlorides in the presence of an in situ generated nickel catalyst derived from a ferrocenylphosphine ligand. 

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