3-Amino-10-chloro-2-hydroxydecanoic

Cyanobacteria blooms can pose an extremely serious threat to human health (970-972), and some of the causative toxins contain halogen. The fresh water toxic cyanobacterium Oscillatoria agardhii produces oscillaginin A (916), which features the novel 3-amino-10-chloro-2-hydroxydecanoic acid, and is the source of the micro-cystins, which are heptatoxins (973). The prolific cyanobacterium Lyngbya majuscula from Curacao has furnished the novel barbamide (917) (974) and dechlorobarbamide (918) (975). Extensive biosynthetic studies show that the amino acids leucine, cysteine, and phenylalanine are involved in barbamide production (976-982). The chlorination of leucine is of great interest and may involve a radical mechanism (976, 980-983). 

Sano T, Kaya K (1997) A 3-Amino-10-chloro-2-hydroxydecanoic Acid-Containing Tetra-peptide from Oscillatoria agardhii. Phytochemistry 44 1503... 

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