5- Amino-4-carboxyethyl-2-methylthiazole

To the previous reaction we related the dehydration of ethyl-2-acetamido-2-thiocarbamoylacetate. This latter compound, heated in the presence of POCI3 20 min at 80°C and then 35 min at 95°C, gives 5-amino-4-carboxyethyl-2-methylthiazole in 77.5% yield. In a similar manner, 2-fonnaminothioacetaniide gives the 5-aminothiazole (718). 

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