5-Amino-3-butylamino

Methyl 3-amino-6-bromo-2-pyrazinecarboxylate Methyl 3-amino-6-bromo-2-pyrazinecarboxylate 4-oxide Methyl 3-amino-5-butylamino-6-chloro-2-pyrazinecarboxylate... 

Schwefeldiimid Bis-[l-cyan-l-methyl-ethyl]- Ell, 589 (R —N = SC12 + Amin) 1,2-Thiazol 3-Amino-5-butylamino-... 

The reaction of dimethyl amino(butylamino)methylenemalonate (1364) and Af-(chlorocarbonyl)isocyanate in benzene afforded (l,3,5-triazin-2-ylidene)malonate (1365) in 52% yield and the hydrochloride salt of the starting material (1364 x HC1) (76ZOR2253). 

Amino-butylamino-methylen)- -ethylester-nitril E15/2, 2156 (CC13 - NH-R) [Amino-(2-methyl-propylamino)-methylen]- -ethylester-nitril E15/2, 2157 (CC13 - NH-R) (Bis-[dimethylamino]-methylen)- -ethylester-nitil E15/2, 1980 (R2N-CO-NR2 + COClj/... 

Amino-butylamino-methylen)- -/erf.-butylester-nitril E15/2, 2157 (CC13 - NH-R)... 

Amino-/ /-[(butylamino)- carbonyljbenzenesulfon- amide Carbutamide C11H17N3O3S 339-43-5 271.336 144.5 ... 

On the other hand, a methyl group adjacent to an amino group at 3 -position produces a bathochromic shift. Thus, 3 -chloro-6 -cyclohexyl-amino-4, 5 -dimethylfluoran (20), 14 3 -n-butylamino-6 -chloro-4 -methylflu-oran (21),15 etc. develop vermilion color. 

The aminopropylation of spermidine into spermine by spermine synthase (SPM synthase) is favored by a higher basicity (ease of protonation) of the nitrogens N-1 and N-4, but also by a lower basicity of N-8 of the butylamino terminal group (more difficult protonation). This last factor enhances the affinity of the substrate for the enzyme. Fluorospermidines could then appear as potential inhibitors of SPM synthase. Indeed, the presence of fluorine atoms in P of an amino group lowers the basicity of the amine the pK value of N-4 is lowered by 2.70 units for... 

CH(CH3)2 C6H5 CTT(CU3)2 c4h9 1 -Isopropyl-2-iso-propylamino-... 2-Butylamino-l-phenyi-... < 1 50 204 206 120-123 l-Isopropyl-2-isopropyl-amino-... 44 82-84... 

In ahnlicher Weise wird 5-Amino-3-butylamino-2-cyan-l,4-naphthochinon mit 1-Amino-alkanen unter UV-Bestrahlung, jedoch unter AusschluB von Luftsauerstoff, in guten Ausbeuten zu 8-Alkylamino-5-amino-3-butylamino-2-cyan-l, 4-naphthochinonen aminiert2. 

Auch aus den Komponenten der Imin-Bildung (z.B. aus 2-Methyl-propanal und tert.-Butylamin) lassen sich durch Reaktion mit Cyan-trimethyl-silan 2-Amino-alkansaure-nitrile (z.B. 2-tert.-Butylamino-3-methyl-butansaure-nitril) herstellen1. 

C(CH,)3 C(CH,), C(CH,), CH3 C(CH3)3 2- tert.-Butylamino-l-( l,3-dithian-2-yl)- 3,3-dimethyl-Toxo-butan 3- ( 1-Adamantyl-amino) -4,4-dimelhyl-2- oxo-nentan 4- ( l-Adamantyl-aminoj-5,5-dimethv/-3- oxo-hexan 58 65 69... 

C in THF, which cleanly led to the formation of (amino)(aryl)carbene Xllla (Scheme 8.8). ° A NMR signal at 8 = 314.2 ppm leaves no doubt of the formation of Xllla. Carbene Xllla is stable for days in solution at —50 °C but undergoes a C—H insertion reaction at room temperature within a few hours, giving rise to the 4,6-di-ferf-butyl-l,l-dimethyl-3-(methyl-rcrt-butylamino)mdane as the major product. It is interesting to note that this reaction, typical of transient singlet and triplet carbenes, has never been observed for diamino carbenes. This striking difference demonstrates the less perturbed character of carbene Xllla. 

The replacement of the dimethylamino group of DNS-C1 by the di-N-butylamino group has led to some improvements in the fluorescence labeling of amino acids. The derivatives are formed in the same manner as the DNS-amino acids (see above), but are less polar and more easily extracted from the reaction mixture [82,83]. The fluorescence characteristics of these derivatives do not differ greatly from the DNS derivatives, but the fluorescence quantum yields are ca. 15% larger in ethyl acetate solution. Bansyl (BNS) derivatives are also suitable for evaluation by MS (see Section 4.4). 

Two other metabolites characterized in the extracts were GS-25433 (2-amino-4-sw-butylamino-6-methoxy-,v-triazine) andGS-31709 (2-amino-4-ethylamino-6-mcthoxy-.y-triazine). 

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