Amino- and Azido-sugar Nucleosides

Several azido- and amino-sugar nucleosides have been shown to exhibit antiviral and antitumour properties, which has triggered interest in their synthesis. In general, aminosugar nucleosides 

5 -Azido-5 -deoxy-nucleosides auid 5 -azido-2, 5 -dideoxy nucleosides have been prepared by a polymer support method, using polystyrenesulphonyl chloride reagent in conjunction with lithium azide,which on triphenylphosphine reduction yielded the corresponding amino-sugar nucleosides.  

Disaccharide nucleosides have been prepared in which neuraminic acid is glycosidically 5 -linked (by Kbnigs-Knorr procedures) to 5-fluorouridine or inosine, giving derivatives with useful immunological activity. ° The 2-nitroimidazole N-glycoside of neuraminic acid has also been reported.  

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