Amino alcohol ligands ester hydrolysis

Base hydrolysis of cis-[Co(en)2X(NH2CH2CH2OCOMe)]2+ (X = C1 or Br) in which the ester of an amino-alcohol is employed as the ligand has also been studied.151 A two-step hydrolysis is observed, the first involving CP or Br- loss and the second ester hydrolysis. It is noteworthy that N-coordination to cobalt prevents the rapid base-catalyzed isomerization of 2-aminoethyl acetate to 2-acetylaminoethanol. 

Simple esters cannot be allylated with allyl acetates, but the Schiff base 109 derived from o -amino acid esters such as glycine or alanine is allylated with allyl acetate. In this way. the o-allyl-a-amino acid 110 can be prepared after hydrolysis[34]. The Q-allyl-o-aminophosphonate 112 is prepared by allylation of the Schiff base 111 of diethyl aminomethylphosphonates. [35,36]. Asymmetric synthesis in this reaction using the (+ )-A, jV-dicyclohex-ylsulfamoylisobornyl alcohol ester of glycine and DIOP as a chiral ligand achieved 99% ec[72]. 

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