Amino acids isosteviol

Kataev VE, Strobykina lY, MUitsina OI, Korochkina MG, Fedorova OV, Ovchinnikova IG, Valova MS, Rusinov GL. Isosteviol and some of its derivatives as receptors and carriers of amino acid picrates Tetrahedron Lett 47 2006 2137-2139. 

Scheme 10.34 Three-component Mannich reaction cataiyzed by isosteviol-derived amino acids.

On the other hand, in 2011, An and coworkers settled a series of isosteviol-amino acids, in which the steric hindrance and the hydrophobic interactions allow to fix the configuration of the common enamine intermediate (Scheme 2.8). Indeed, even though various amphiphilic catalysts were... 

Y. An, Q. Qin, C. Wang, J. Tao, Chin. J. Chem. 2011, 29, 1511-1517. Isosteviol-amino acid conjugates as highly efficient organocatalysis for the asymmetric one-pot three-component Mannich reactions. 

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