Amino acids Aminoalcohols

Nu cyanide alkoxydes thiolates azoles ammonia primary amines secondary amines amino acids aminoalcohols... 

Amino acids, aminoalcohols, afloqualone (a muscle relaxant), primaquine (an antimalarial). (-t-)-18-crown-6 tetracarboxylic acid bonded to 3-aminopropylsilanized silica gel 1290)... 

In determination of the enantiomeric purity of aliphatic primary amines, the use of (S-aminoalcohols and ot-amino acids 1R(—)-myrtenal as a derivatising agent has been tested.1... 

Identification of carboxy-terminal amino acids was also attempted. Studies by Bergmann and his associates in the 1930s (see below) had characterized various peptidases with differing specificities. One of these was carboxypeptidase which required a free carboxy terminus adjacent to the peptide bond to be hydrolyzed. The specificity of the enzyme was limited but Lens in 1949 reported alanine to be at one end of insulin. Fromageot and his colleagues (1950) and Chibnall and Rees (1951) reduced the carboxy termini to B-aminoalcohols and showed glycine as well as alanine to be carboxy-terminal. Hydrazinolysis was also attempted the dry protein was treated with hydrazine at 100 °C for 6 h so that the carboxy-terminal amino acid was released as the free... 

Aminoalcohol Ring Cleavage of Nitrile Oxide Cycloadducts Synthesis of Amino Polyols, Amino Sugars, and Amino Acids... 

The chiral ligand (44) was prepared starting from the cyclic a-amino acid (S)-proline80). Recently, similar chiral catalysts and related molybdenum complexes involving optically active N-alkyl-P-aminoalcohols as stable chiral ligands and acetylacetone as a replaceable bidentate ligand, were designed for the epoxidation of allylic alcohols with alkyl hydroperoxides which could be catalyzed by such metal complexes 8,). 

Enantiomerically pure aminoalcohols, which are readily available by reduction of a-amino acids, can be converted into alkoxycarbonylating reagents suitable for the solid-phase synthesis of oligocarbamates (Figure 16.26). Particularly convenient alkoxycarbonylating reagents are 4-nitrophenyl carbonates, which can be prepared from alcohols and 4-nitrophenyl chloroformate, and which react smoothly with aliphatic primary or secondary amines to yield the corresponding carbamates. 

Chiral intermediates (e.g., non-proteinogenic amino acids, alcohols, amines, polyols, aminoalcohols, and acids)... 

Pteridine synthesis from pyrazine precursors are usually applied in such cases where the formation of special derivatives cannot be achieved easily by the pyrimidine approach. Methyl 3-amino-2-pyrazinecarboxylate (362) reacts with thiophosgene to give the corresponding 3-isothiocyanato derivative (363) which cyclizes with primary amines, arylalkylamines, aminoalcohols, amino acids,... 

An improved electrochemical synthesis of chiral oxazolidin-2-ones from 1,2-aminoalcohols was achieved by reaction with C02 and electrogenerated acetonitrile anion <02TL5863>. The reaction of A-protected amino acids with paraformaldehyde was greatly accelerated by microwave irradiation <02TL9461>. Oxazolidin-2-ones were synthesised by sulfur assisted thiocarbonylation of 2-aminoethanols with carbon monoxide and subsequent oxidative cyclisation with molecular oxygen <02T7805>. 

Any kind of C-Mannich base has been actually allowed to react with a variety of amines, including aminoalcohols and amino acids. Cyclic amines, - including optically active derivatives, - and amides arc also employed as are a number of aromatic heterocycles. 

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