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Amino acid sequence nAChR subunits

Similar nAChRs are also found in the brain.621 631 632 However, they are not identical but have at least 17 differing amino acid sequences (al-alO, (31-(34, y, 8, and e). The neuromuscular junction receptor (muscle type) from fish is described as (al)2 (31 my / S.626 The brain contains homopentamers of subunits a7, a8, and a9 as well as various heteropentamers. The various forms possess different affinities for acetylcholine and for antagonists such as nicotine.633 634 In the brain the highest affinity for nicotine is shown by an a4 32 form, which represents over 80% of the nAChR in mammalian brain.634 635 Knockout mice in which the (32 subunit gene has been deleted lose their sensitivity to nicotine. [Pg.1785]

Table 29.1.2 Amino acid sequence in loop D of vertebrate and insect nAChR subunits. (Data taken from Shimomura et al., 2002.)... Table 29.1.2 Amino acid sequence in loop D of vertebrate and insect nAChR subunits. (Data taken from Shimomura et al., 2002.)...
In spite of a relatively low degree of overall sequence identity (15-18% identical amino acids with the various subunits of nAChR), the sequence alignment led to correct assignment of the important M2 helix in Rdl to that of nAChR, so that construction of a... [Pg.381]

See other pages where Amino acid sequence nAChR subunits is mentioned: [Pg.62]    [Pg.117]    [Pg.198]    [Pg.90]    [Pg.178]    [Pg.118]    [Pg.84]    [Pg.380]    [Pg.273]    [Pg.853]    [Pg.89]    [Pg.853]   
See also in sourсe #XX -- [ Pg.180 ]



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