Amino acid esters inclusion complex

The rates of hydrolysis of the trifhioroacetates (201 X = H, Me) increase in a nonlinear fashion in the presence of jS-CD. Some differences in rate between the two substrates have been explained as being due to different modes of inclusion.173 The novel CDs (202) and (203) have been synthesized in 45% and 66% yields, respectively, and their complexation with various l/d amino acids have been examined. Importantly, (202) and (203) can be detected by fluorescence spectroscopy and they can recognize the size and shape but also the chirality of the amino acids.174 A /j-CD dimer with a linking bipyridyl group (204) has been synthesized and shown to bind both ends of potential substrates into two different cavities of the CD holding the substrate ester carbonyl group directly above a Cu(H) ion bound to die bipyridyl unit. This achieves... 

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