Transaminases amino acid amide

S) Amino Acid Amide Transaminases. Mention was made previously (see Amidases) of the observations by Greenstein and co-workers that the addition of pyruvic and other a-keto acids to liver extracts accelerated the formation of ammonia from glutamine and asparagine. This reaction has been shown by Meister and co-workers to involve a transamination reaction different in several respects from those previously discussed. The reaction for glutamine may be formulated as follows ... 

Amino Acid Amide Transaminases Meister and co-workers (18, 248, 260, 270, 271, 325, 354-356) have established the existence of two separate transaminases which catalyze the following reactions ... 

Studies to date indicate that transaminases are specific for L-amino acids and a-keto acids. Peptides and other derivatives of amino acids, such as amides and A -substituted amino acids, are not active. Recently it has been reported that E. coli extracts catalyze a transamination reaction between adenine and a-ketoglutaric acid. ... 

---