Amines reaction with Grignard

The benzotriazole moiety of iV-(a-aminoalkyl)benzotriazoles is readily replaced by hydride upon reduction with sodium borohydride, or with a carbanion by reaction with Grignard or lithium reagents. These are two most important reactions of benzotriazole derivatives from which versatile routes have been developed for the synthesis of primary, secondary, and tertiary amines. 

Imido compounds have been made by interaction of amines with Grignard or dimagnesium compounds. The reaction with Grignards gives what are termed magnesylamines. ... 

This linker was synthesized starting from commercially available aldehyde-modified support 21 [28]. After reaction with Grignard compound 22, alcohol 23 was obtained, which was then transformed with CDI to the activated species ready for the attachment of the amine to yield 24. The desired secondary amine was liberated by treatment with fluoride ions (Scheme 9). The linker is versatile in that it can be used not only for the attachment of amines but also for the attachment of carboxylic acids and alcohols. 

Phosphorinanones have been utilized as substrates for the preparation of alkenes/ amines,indoles, - and in the synthesis of a series of secondary and tertiary alcohols via reduction,and by reaction with Grignard and Refor-matsky - reagents. Phosphorinanones have also been used as precursors to a series of 1,4-disubstituted phosphor ins. The use of 4-amino-l,2,5,6-tetrahydro-l-phenylphosphorin-3-carbonitrile for the direct formation of phosphorino-[4,3-< ] pyrimidines has been reported. ... 

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