Amine Particles Using Crosslinking Agents

Coupling to Amine Particles Using Crosslinking Agents 

Another possible route to coupling ligands to amine particles is to use a bifunctional crosslinking agent to react with the amines and provide another reactive group at the other end to couple with the ligand. In this approach, virtually any reactive group desired can be formed on the 

A homobifunctional amine-reactive compound can be used initially to modify the amine groups on particles, while leaving the remaining amine-reactive groups available to couple with ligands. This type of reaction must be done with the crosslinker in great excess to prevent polymerization of the amine particles themselves. There must be enough crosslinker present 

Secondary amine linkage with terminal aldehyde 

Schiff base formation and addition to double bonds 

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