Amine alkanone imine

Initial imine or iminium generation from amines can be used to allow C-X (X = heteroatom) or C-C bond formation. Thus, anilines substituted in the orf/zo-position with X-H functionalities (X = 0, NMe, S) have been dehy-drogenatively condensed with benzylamines under mpg-CN photocatalysis to yield the corresponding benzofused heterocycles [122]. Via iminium intermediates, AI-aryl-l,2,3,4-tetrahydroisoquinolines could be dehydrogenatively coupled photocatalytically by mpg-CN to various carbon nucleophiles derived from nitroalkanes, malonates, and 2-alkanones, and the latter via tandem organocatalysis with proline [124]. 

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